For the third time in 2018, Max Holloway has been forced out of a UFC fight.

The UFC featherweight champion will not defend his title against Brian Ortega at UFC 226 on Saturday night in Las Vegas due to concussion-like symptoms, a source confirmed late Wednesday night.

ESPN first reported the story.

Holloway hasn’t fought since a third-round TKO of Jose Aldo in December. He had a fight against Frankie Edgar in March fall through because of an ankle injury suffered a month before the scheduled fight.

He attempted to step up and fight Khabib Nurmagomedov on six days’ notice in April for the 155-pound title, but wasn’t cleared by doctors the day before the fight due to a severe weight cut.

Holloway attempted to lose 30 pounds in less than a week.

According to a statement provided from Holloway’s management team to ESPN, Holloway was rushed to an emergency room on Monday night and cleared on Tuesday.

After Wednesday’s open workouts, Holloway was “very hard to wake up (and) when he did he had flashing vision and slurred speech.”

He was back in the emergency room on Wednesday night to undergo more tests.

In an interview with the Star-Advertiser before leaving for Las Vegas, Holloway said, “this is a superfight for the 145 (pounders). It’s a fight that doesn’t have the likes of Frankie Edgar and Jose Aldo for the first time in 10 years.”

Holloway’s current 12-fight winning streak is the fifth-longest in UFC history.