GREEN BAY, Wis.  — Green Bay Packers running back Ryan Grant is out for the season after being placed on injured reserve with an ankle injury he got in the season-opening win against the Eagles.

The club also placed former first-round pick Justin Harrell on injured reserve and signed running back Dimitri Nance and defensive end Jarius Wynn to fill their spots on the roster.

Packers coach Mike McCarthy said Monday that Grant sustained a “significant” ankle injury that involved ligament damage in Green Bay’s 27-20 win at Philadelphia on Sunday.

Grant had run for 1,200 yards in each of the last two seasons. The Packers had only backup running back Brandon Jackson and fullback John Kuhn on the roster as replacements before signing Nance.