PANAMA CITY >> Former Panamanian dictator Manuel Noriega, a onetime U.S. ally who was ousted as Panama’s dictator by an American invasion in 1989, died late today at age 83.

Panamanian President Juan Carlos Varela wrote in his Twitter account that “the death of Manuel A. Noriega closes a chapter in our history.”

Varela added, “His daughters and his relatives deserve to mourn in peace.”

Noriega ruled with an iron fist, ordering the deaths of those who opposed him and maintaining a murky, close and conflictive relationship with the United States.

At the apex of his power he wielded great influence outside the country as well thanks to longstanding relationships with spy agencies around the world, said R.M. Koster, an American novelist and biographer of Noriega who has lived in Panama for decades.

After his downfall, Noriega served a 17-year drug sentence in the United States, then was sent to face charges in France. He spent all but the last few months of his final years in a Panamanian prison for murder of political opponents during his 1983-89 regime.

He accused Washington of a “conspiracy” to keep him behind bars and tied his legal troubles to his refusal to cooperate with a U.S. plan aimed at toppling Nicaragua’s leftist Sandinista government in the 1980s.

In recent years Noriega suffered various ailments including high blood pressure and bronchitis.

In 2016, doctors detected the rapid growth of a benign brain tumor that had first been spotted four years earlier, and in the following January a court granted him house arrest to prepare for surgery on the tumor.

He is survived by his wife Felicidad and daughters Lorena, Thays and Sandra.

Following Noriega’s ouster Panama underwent huge changes, taking over the Panama Canal from U.S. control in 1999, vastly expanding the waterway and enjoying a boom in tourism and real estate.

Today the Central American nation has little in common with the bombed-out neighborhoods where Noriega hid during the 1989 invasion, before being famously smoked out of his refuge at the Vatican Embassy by incessant, loud rock music blared by U.S. troops.

Known mockingly as “Pineapple Face” for his pockmarked complexion, Manuel Antonio Noriega was born poor in Panama City on Feb. 11, 1934, and was raised by foster parents.

He joined Panama’s Defense Forces in 1962 and steadily rose through the ranks, mainly through loyalty to his mentor, Gen. Omar Torrijos, who became Panama’s de facto leader after a 1968 coup.

As Torrijos’ intelligence chief, Noriega monitored political opponents and developed close ties with U.S. intelligence agencies guarding against possible threats to the canal. Two years after Torrijos died in a mysterious plane crash in 1981, Noriega became the head of the armed forces and Panama’s de facto ruler.

Noriega was considered a valued CIA asset and was paid millions of dollars for assistance to the U.S. throughout Latin America, including acting as a liaison to Cuban leader Fidel Castro.

Noriega also helped the U.S. seize drugs at sea and track money laundering in Panama’s banks, and reported on guerrilla and terrorist activities.

Washington ultimately soured on him, especially after a top political opponent was killed in 1985 and Noriega appeared to join forces with Latin American drug traffickers. Foes in the Panamanian military attempted several coups but failed, and their leaders were summarily executed by firing squad.

The beginning of his downfall came in 1988 when federal grand juries in the Florida cities of Miami and Tampa indicted Noriega on drug-trafficking charges.

U.S. President George H.W. Bush ordered the invasion in December 1989, and Noriega was captured and taken to Miami. During the operation, 23 U.S. military personnel died and 320 were wounded, and the Pentagon estimated 200 Panamanian civilians and 314 soldiers were killed.

Jurors convicted Noriega in April 1992 of eight of 10 charges. Under the judge’s instructions, they were told not to consider the political side of the case — including whether the U.S. had the right to invade Panama and bring Noriega to trial in the first place.

During his years at a minimum-security federal prison outside Miami, Noriega got special POW treatment, allowed to wear his Panamanian military uniform and insignia when in court.

After completing his 17-year sentence in 2007, Noriega was extradited to France and received a seven-year sentence for money laundering.

But Panama wanted Noriega to return to face in-absentia convictions and two prison terms of 20 years for embezzlement, corruption and murder of opponents, including military commander Moises Giroldi, who led a failed rebellion on Oct. 3, 1989, and Hugo Spadafora, whose decapitated body was found in a mailbag on the border with Costa Rica in 1985.

In mid-2011, France approved his extradition to Panama.

Noriega broke a long silence in June 2015 when he made a statement from prison on Panamanian television in which he asked forgiveness of those harmed by his regime.

“I feel like as Christians we all have to forgive,” he said, reading from a handwritten statement. “The Panamanian people have already overcome this period of dictatorship.”

Meanwhile, families of more than 100 who were killed or disappeared during his rule are still seeking justice.