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Researchers describe Alzheimer’s as ‘Type 3 Diabetes’

  • NEW YORK TIMES

    An Alzheimer’s patient gets an infusion for a drug trial aimed at slowing down the progression of the disease at Yale-New Haven Health in New Haven, Conn., in 2015. Patients in the trial needed to have the gene variant known as ApoE4, which increases the risk of developing late-onset Alzheimer’s.

Alzheimer’s disease is common and mysterious, well-documented and hidden. Though it affects an estimated 5.4 million Americans today (5.3 million are 65 or older), by 2050 almost 14 million people in the U.S. are expected to have this condition.

Although there are medications available, none slows the progress of the disease and none has come close to a cure. But there is hope due to new clues about diet.

Research published in JAMA Neurology seems to best explain what goes on in the brain when Alzheimer’s develops: In that study, the two known “bad actors” associated with loss of cognitive function are amyloid plaques and tau tangles. We don’t know that they’re the direct cause of the loss of brain functioning, but one hypothesis holds that the formation of plaques may trigger conversion of tau into a toxic version of itself; the toxic tau then makes the plaques even worse, and those two scramble transmissions of info and disrupt memory, emotions and more.

Another hypothesis holds that it is inflammation, often worsened by excess sugar.

But how does this all get started? That’s the question!

INTRODUCING TYPE 3 DIABETES

New research indicates that inflammation is worsened by dysfunction of glucose metabolism in the brain. That’s what’s behind the newly coined phrase, “Alzheimer’s as Type 3 Diabetes.” Here’s the current research on glucose levels and your brain:

>> Increases in blood glucose levels are related to higher brain glucose levels, especially in your last decades of life.

>> Higher brain levels of glucose — overwhelming levels — are a precursor to changes in neurological functions. Those changes happen before symptoms of Alzheimer’s appear and seem to be associated with formation of plaques and dysregulation of tau.

>> And then there’s the obstructive sleep apnea connection. A new study shows that older folks with it are at increased risk for Alzheimer’s. Turns out, obstructive sleep apnea is associated with glucose intolerance and insulin resistance, whether or not a person is obese. And glucose intolerance and insulin resistance cause elevated glucose levels in the blood and eventually in the brain. That then leads to neuron function disruption and formation of plaques and toxic tau protein — Type 3 diabetes!

WHAT YOU CAN DO

What this means for YOU if you are one of the 100 million Americans with prediabetes or diabetes: Act now to reduce bodily inflammation and restore healthy blood sugar levels.

>> Walk 10,000 steps a day and do strength training two to three days a week.

>> Eat seven to nine servings of fruits and veggies a day.

>> Avoid added sugars, syrups and simple carbs; they are brain cell killers.

>> Control your stress response with meditation and seven to eight hours of good-quality sleep every night.

>> If you have obstructive sleep apnea, get treated!

>> If you need medication to control your blood glucose, get it, use it and see your doctor regularly to make sure you’re on track.

Your brain will thank you decades from now, when you’re still thinking clearly!


Mehmet Oz, M.D., is host of “The Dr. Oz Show,” and Mike Roizen, M.D., is Chief Wellness Officer and Chair of Wellness Institute at Cleveland Clinic. Email questions to youdocsdaily@sharecare.com.


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