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Local clinical research study searching for Alzheimer’s cure

Presented by:
Valden Medical

Valden Medical

Do you or someone you love have Alzheimer’s disease?

Valden Medical, a Honolulu-based clinical research site, led by Principal Investigator, Denis Mee-Lee, MD, has been designated as one of only three US research centers to conduct a ground-breaking study. The study is currently seeking participants. A free memory and medical evaluation will be assessed to determine qualification.

This stem cell study is FDA approved, IRB monitored, Phase 1/2, randomized, double-blind, placebo-controlled trial of autologous stem cells derived from the abdominal adipose tissue of mild to moderate Alzheimer’s patients.

Suitable subjects must have probably mild-to-moderate Alzheimer’s disease according to the NINCDS-ADRDA criteria, be aged 50 years or above, and on a stable dosage of one of the currently available medications (donepezil, galantamine, memantine, rivastigmine, or their combinations) consistently for 3 months or more. They must have an identified adult caregiver who has regular contact with the subject and agrees to accompany the subject to each study visit.

While there is no known cure at this time, there are three to four medications currently approved by the FDA for the treatment of Alzheimer’s. However, these medications are only partially effective in reducing the downward course of the illness.

Nationally, Alzheimer’s affects six to 20% of the population aged 65 to 75 and increases to about 50% of the population by age 85. Because Hawaii has a higher proportion of elderly people, Alzheimer’s is quite common locally.

Alzheimer’s is a gradual and progressive deterioration of brain functions. It initially affects recent memory – names, places, dates and events. The memory loss gets worse over the course of months to years and starts to affect the person’s behavior, coping with daily tasks, personality, mood and relationships. It destroys the ability to reason.

The cause of Alzheimer’s is yet to be discovered, but we know that there are genetic, biochemical, anatomical and physiological elements involved. We are not able to determine the specific cause of a particular person’s condition but there is a lot of research going into both understanding the causes and identifying the problems as early as possible.

There are 10 warning signs of Alzheimer’s:

1. Memory loss
2. Difficulty in performing familiar tasks
3. Problems with language
4. Disorientation to time and place
5. Poor or decreased judgment
6. Problems with abstract thinking
7. Misplacing things
8. Negative changes in mood or behavior
9. Changes in personality
10. Loss of initiative

Individuals may lower their risk of getting Alzheimer’s by keeping mentally active, socializing frequently, getting organized, having a healthy diet, exercising daily, managing their chronic conditions and minimizing exposure to toxins such as cigarette smoke and air pollution.

If you or your loved one is interested in receiving more information about the study, please visit

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