LOUISVILLE, Ky. >> Kris Jenkins made two free throws with 13.3 seconds remaining, Jalen Brunson added two more with 3.5 seconds left and second-seeded Villanova upset top-seeded Kansas 64-59 on Saturday night in the NCAA Tournament South Region final to reach the Final Four.

Mikal Bridges and Josh Hart each made big steals in the final minute to help the Wildcats (33-5) pull off the upset and end the Jayhawks’ 17-game winning streak. The Wildcats are back in the Final Four for the first time since 2009, and they can credit balanced scoring and ferocious defense.

Jenkins, Hart and Ryan Arcidiacono each scored 13 points for the Wildcats. They used a 10-0 run to take a 50-45 lead and get key baskets and plays down the stretch in beating the Jayhawks (33-5).

Devonte’ Graham had 17 points, and Frank Mason III and Wayne Selden Jr. added 16 each for Kansas.

Villanova got 10 points from Daniel Ochefu, including a big jumper with 6:14 left, just one of many big plays the Wildcats made to preserve the lead after finally wresting it from Kansas.

It wasn’t easy. Mason scored five points and the Jayhawks cut it to 60-59 with 15 seconds left. But Arcidiacono preceded that with four free throws before Jenkins and Brunson followed with two more as the Wildcats made 18 of 19 at the line and all eight in the final 33 seconds.

Darryl Reynolds had two free throws and Bridges had a key tip-in for the Wildcats as well.

Villanova gets to pursue its second national title in its fifth Final Four berth, though the NCAA vacated its 1971 appearance because star Howard Porter had signed with an agent. The Wildcats will face Oklahoma next Saturday in Houston.

More importantly, the Wildcats did what no team had been able to over two months and really wasn’t expected to in knocking out the tournament favorite.

Both teams had been ranked No. 1 this season and have been winning even bigger in the tournament.