DES MOINES, Iowa » It’s all about the odds.

With the majority of possible combinations of Powerball numbers in play, someone is almost sure to win the game’s highest jackpot during tonight’s drawing, a windfall of hundreds of millions of dollars — and that’s after taxes.

The problem, of course, is those same odds just about guarantee the lucky person won’t be you.

The chances of winning the estimated $600 million prize remain astronomically high: 1 in 175.2 million. That’s how many different ways you can combine the numbers when you play. But lottery officials estimate about 80 percent of those possible combinations have been purchased, so now’s the time to buy.

"This would be the roll to get in on," said Iowa Lottery CEO Terry Rich. "Of course there’s no guarantee, and that’s the randomness of it, and the fun of it."

That hasn’t deterred people across Powerball-playing states — 43 plus Washington, D.C., and the U.S. Virgin Islands — from lining up at gas stations and convenience stores today for their chance at striking it filthy rich.

At a mini market in the heart of Los Angeles’ Chinatown, employees broke the steady stream of customers into two lines: One for Powerball ticket buyers and one for everybody else. Some people appeared to be looking for a little karma.

"We’ve had two winners over $10 million here over the years, so people in the neighborhood think this is the lucky store," employee Gordon Chan said as he replenished a stack of lottery tickets on a counter.

Workers at one suburban Columbia, S.C., convenience store were so busy with ticket buyers that they hadn’t updated their sign with the current jackpot figure, which was released Friday. Customer Armous Peterson was reluctant to share his system for playing the Powerball. The 56-year-old was well aware of the long odds, but he also knows the mantra of just about every person buying tickets.

"Somebody is going to win," he said. "Lots of people are going to lose, too. But if you buy a ticket, that winner might be you."

The latest jackpot is the world’s second largest overall, just behind a $656 million Mega Millions jackpot in March 2012. The $600 million jackpot, which could grow before the numbers are drawn at 4:59 p.m. Hawaii time today, currently includes a $376.9 million cash option.

Charles Hill of Dallas says he buys lottery tickets every day. And he knows exactly what he’d do if he wins.

"What would I do with my money? I’d run and hide," he said. "I wouldn’t want none of my kinfolks to find me."

Clyde Barrow, a public policy professor at the University of Massachusetts-Dartmouth, specializes in the gaming industry. He said one of the key factors behind the ticket-buying frenzy is the size of the jackpot — people are interested in the easy investment.

"Even though the odds are very low, the investment is very small," he said. "Two dollars gets you a chance."

That may be why Ed McCuen has a Powerball habit that’s as regular as clockwork. The 57-year-old electrical contractor from Savannah, Ga., buys one ticket a week, regardless of the possible loot. It’s a habit he didn’t alter today.

"You’ve got one shot in a gazillion or whatever," McCuen said, tucking his ticket in his pocket as he left a local convenience store. "You can’t win unless you buy a ticket. But whether you buy one or 10 or 20, it’s insignificant."

Seema Sharma doesn’t seem to think so. The newsstand employee in Manhattan’s Penn Station has purchased $80 worth of tickets for herself. She also was selling tickets all morning at a steady pace, instructing buyers where to stand if they wanted machine-picked tickets or to choose their own numbers.

"I work very hard — too hard — and I want to get the money so I can finally relax," she said. "You never know."

Officials will conduct the drawing live tonight from Tallahassee, Fla.

Associated Press Writers Jeffrey Collins in Columbia, S.C., Betsy Blaney in Lubbock, Texas, Russ Bynum in Savannah, Ga., John Rogers in Los Angeles and Verena Dobnick in New York contributed to this report.