NEW YORK >> U.S. stocks took their biggest loss in more than six weeks today as investors reacted to mounting evidence that hiring has slowed down. Energy and health care companies fell sharply, and so did retailers.

Stocks slumped after ADP, a payroll processing company, said private businesses added fewer jobs in June than investors had expected. The losses deepened in afternoon trading.

Bond prices fell and yields jumped, which hurt companies that pay large dividends, such as major drug companies and real estate investment trusts. Retailers sank after L Brands, the parent company of Victoria’s Secret, reported weak sales in June.

The ADP survey was the latest piece of evidence that hiring has slowed down in recent months. That has investors worried, because the European Central Bank may start raising rates soon and rates are already rising in the U.S. Higher interest rates tend to slow down economic growth.

“If rates rise meaningfully, it will end up hampering growth expectations,” said Krishna Memani, chief investment officer at Oppenheimer Fund.

The Standard & Poor’s 500 index dropped 22.79 points, or 0.9 percent, to 2,409.75. The Dow Jones industrial average fell 158.13 points, or 0.7 percent, to 21,320.04. The Nasdaq composite sank 61.39 points, or 1 percent, to 6,089.46. The Russell 2000 index, which is comprised of smaller, more U.S.-focused companies, shed 19.33 points, or 1.4 percent, to 1,400.81.

ADP’s survey showed that private U.S. businesses added 158,000 jobs in June, and the firm lowered its estimates for job growth in April and May. The unemployment rate is at 40-year lows, but there isn’t much evidence that wage gains and economic growth are speeding up.

“We were expecting a significantly higher growth rate in the second quarter,” said Memani. “It’s not panning out that way.”

All of the 61 health care companies listed on the S&P 500 lost ground. Biotech drugmaker Amgen declined $2.54, or 1.5 percent, to $171.72 and medical device maker Medtronic lost $1.64, or 1.8 percent, to $87.26.

Drugmaker Merck skidded $1.06, or 1.7 percent, to $63.10 after it stopped two studies of its cancer drug Keytruda as a treatment for multiple myeloma. Merck said more patients who were treated with Keytruda died, and the Food and Drug Administration halted the studies because the risks of a treatment regimen that included Keytruda outweighed the potential benefits.

L Brands said its sales fell 6 percent in June as the company continues to struggle with the effects of ending its swimwear business. The stock gave up $7.62, or 14.1 percent, to $46.49, by far the largest loss of any S&P 500 company. Athletic apparel maker Under Armour fell $1.49, or 6.7 percent, to $20.65 and Hanesbrands shed 65 cents, or 2.8 percent, to $22.53. Signet Jewelers lost $2.52, or 3.9 percent, to $61.57.

Bond prices skidded. The yield on the 10-year Treasury note rose to 2.36 percent from 2.33 percent. Investors sold shares of big-dividend stocks, as the rising bond yields made those stocks less appealing to investors seeking income.

Technology companies, which have been in a swoon over the last month, turned lower again. Apple sank $1.36 to $142.73 and Intel dropped 71 cents, or 2.1 percent, to $33.63. Electronic storage company Seagate Technology retreated $1.73, or 4.4 percent, to $37.29.

The parent company of QVC will buy the rest of Home Shopping Network that it didn’t already own for about $2.6 billion in stock. Liberty Interactive said it will value QVC at $40.36 a share in the deal. It already owns a 38 percent stake in HSN, which jumped $8.40, or 26.8 percent, to $39.70. Liberty Interactive fell 30 cents, or 1.2 percent, to $24.16.

Global leaders arrived in Hamburg, Germany, for the G-20 summit as the U.S. and South Korea continued to respond to North Korea’s recent missile test. South Korean jets and navy ships today fired missiles into the ocean during drills, a display of military power two days after North Korea test-launched its first intercontinental ballistic missile.

The VIX, a measurement of how much volatility investors expect, climbed 13 percent to 12.53, although that is still a relatively low level.

Energy companies faded even though fuel prices increased. Benchmark U.S. crude oil rose 39 cents to $45.52 a barrel in New York. Brent crude, used to price international oils, added 32 cents to $48.11 a barrel in London.

Wholesale gasoline added 3 cents to $1.53 a gallon. Heating oil remained at $1.48 a gallon. Natural gas climbed 5 cents to $2.89 per 1,000 cubic feet.

Gold inched up $1.60 to $1,223.30 an ounce. Silver gained 9 cents to $15.98 an ounce. Copper remained at $2.66 a pound.

The dollar slipped to 113.26 yen from 113.35 yen. The euro rose to $1.1423 from $1.1340.

Germany’s DAX fell 0.6 percent and the CAC 40 in France was 0.5 percent lower. The British FTSE 100 index lost 0.4 percent. Japan’s Nikkei 225 fell 0.4 percent and the Kospi in South Korea edged down less than 0.1 percent. The Hang Seng of Hong Kong shed 0.2 percent.