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Coronavirus cases rising sharply across U.S., but deaths are still down

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                                People waiting in line to enter a grocery store wear COVID-19 protective masks today in McCandless, Pa. Gov. Tom Wolf issued a more-expansive mask order this week as the coronavirus shows new signs of life in Pennsylvania.


    People waiting in line to enter a grocery store wear COVID-19 protective masks today in McCandless, Pa. Gov. Tom Wolf issued a more-expansive mask order this week as the coronavirus shows new signs of life in Pennsylvania.

After a minor late-spring lull, the number of confirmed coronavirus cases in the United States is once again on the rise. States like Arizona, Florida and Texas are seeing some of their highest numbers to date, and as the nation hurtles further into summer, the surge shows few signs of stopping.

And yet the virus appears to be killing fewer of the people it infects. In April and May, COVID-19, the disease caused by the coronavirus, led to as many as 3,000 deaths a day, and claimed the lives of roughly 7% to 8% of infected Americans. The number of daily deaths is now closer to 600, and the death rate is less than 5%.

In general, experts see three broad reasons for the downward trend in the rate of coronavirus deaths: testing, treatment, and a shift in whom the virus is infecting. The relative contribution of these factors is not yet clear. And because death reports can lag diagnoses by weeks, the current rise in coronavirus cases could still portend increases in mortality in the days to come.

Testing on the rise

Since mid-March, when the coronavirus was declared a national emergency, diagnostic testing for the coronavirus has risen significantly. More than 600,000 tests are administered each day in the United States, up from about 100,000 a day in early spring. Although the nation is still falling short of the millions of daily tests that experts have called for, the increased testing has identified many more infected individuals with mild or no symptoms, driving down the overall proportion of patients who die from COVID-19, said Caitlin Rivers, a senior scholar at the Johns Hopkins Center for Health Security.

And with more tests available, infections are often identified earlier, “which allows us to intervene earlier,” said Saskia Popescu, a hospital epidemiologist and infectious disease expert in Arizona. Many treatments seem to work best when given well before people are at death’s door.

As the weeks have worn on, doctors and nurses have also gained a better handle on how to treat the coronavirus. In several states, emergency departments are no longer overflowing; between April and June, nationwide hospitalizations dropped to less than 30,000 from nearly 60,000, according to the COVID Tracking Project. That may have eased the strain on exhausted employees and limited medical supply chains, including those that keep lifesaving equipment like ventilators in stock, said Dr. Taison Bell, a physician specializing in infectious disease and pulmonary and critical care at the University of Virginia. Under less pressure, hospitals are now “better able to take care of critically ill patients,” he said.

More and better treatments

Health care workers have also become more knowledgeable about promising treatments and palliative care options to combat the coronavirus and its effects. For instance, prone positioning, in which patients are flipped onto their stomachs, can ease respiratory distress by opening up the lungs. Critically ill individuals are also now known to be vulnerable to excessive blood clotting, and may benefit from blood thinners. And the steroid dexamethasone appears to reduce deaths among patients with severe COVID-19, although the data demonstrating this emerged only recently. (Another drug, an antiviral called remdesivir, seems to speed recovery, but does not appear to have notable effects on mortality.)

“Before, it felt like we were stumbling in the dark,” Bell said. “It feels a little bit better now.”

A new patient population

A shifting patient population is probably also altering the disease’s dynamics. Coronavirus-related hospitalizations increase with age, and elderly individuals remain some of those hardest hit by the coronavirus; patients over 65 account for 8 out of 10 deaths from COVID-19, according to the Centers for Disease Control and Prevention. But younger people now make up a growing proportion of cases, and they are less likely to die from the disease. In Arizona, people ages 20-44 now account for nearly half of all cases. In Florida, which just recorded more than 10,000 new cases in a single day, the median age of residents testing positive has dropped to 35 from 65. And in Texas, more than half of those testing positive are under the age of 50.

Numerous states recently began reopening their economies, which might be driving some of the youthful bias, said Natalie Dean, an infectious disease epidemiologist in Florida, where new cases are hitting record highs. People in their 20s and 30s have returned to bars and beaches; working-age employees have resumed jobs that cannot be done from home.

“We know that’s high-risk,” Dean said. “We’re hearing a lot of reports of clusters being linked to these places” as they open back up.

At the same time, elderly individuals, as well as those with underlying health conditions thought to exacerbate COVID-19, may be warier of exposure, said C. Brandon Ogbunu, a computational biologist and disease ecologist at Yale University. “Early on, this disease ripped through older populations with such aggression,” he said. “It’s possible that’s where the message was felt the most strongly.”

Moreover, nursing homes and other facilities that harbor vulnerable populations may be working harder to protect their residents, Dean said. In general, “We now have a better set of tools to keep our communities safer,” he said. “More people are wearing masks. We’re better at sanitizing things.”

Of course, “Young people don’t live in isolation,” Bell said. They are still mingling with older members of the population — potentially seeding transmission events that have yet to appear.

Looking ahead

Experts can’t be sure, but behaviors like mask wearing, physical distancing and hygiene may also be reducing the dose of coronavirus that people encounter in the population at large, Dean said. The amount of virus that individuals carry may influence the severity of their symptoms. But so far, there is no evidence that this dynamic is contributing to the lower mortality rate in the United States.

There is also no indication that the death rate is lower because the coronavirus itself has become less deadly, Ogbunu said. Mutation is a normal part of any virus’s evolutionary trajectory, but these genetic changes are often inconsequential.

Given the recent rise in infections, the dip in coronavirus mortality will not necessarily last. As more people socialize, those with milder infections might end up ferrying the pathogen to vulnerable individuals. As states reopen, local leaders are urging residents to continue physical distancing and to wear masks. But even tempered by warnings, moves back toward normalcy could inadvertently signal to people that the worst is already over, Popescu said.

Experts are also reluctant to place too much emphasis on falling death rates. “We’re training a lot of attention on the idea of mortality,” said Dr. Jennifer Tsai, an emergency medicine physician at Yale University. Behind that picture, she added, there is a great deal of suffering. Reports from around the world have painted a sobering portrait of chronic COVID-19 syndromes, some of which last for months. Patients may be saddled with physical and emotional distress that persists long after the virus has left their bodies.

“Death is not the only outcome,” Dean said. And people marginalized by race, ethnicity and social standing will inevitably bear more of the disease burden than others, Tsai added. “The risk and the mortality is going to be passed on to the most vulnerable, no matter who gets infected first,” she said.

Recent upswings in coronavirus case numbers leave experts apprehensive of what’s to come. Death, when it occurs, tends to trail infection by about 2-4 weeks. Early on in the pandemic, when testing focused on patients with worrisome symptoms, the typical lag between case and death reporting was a week or two. Now that diagnostic testing is more widespread, that interval has widened.

Two weeks into a new round of coronavirus cases, the United States may be verging on another wave of deaths. Already, hospitalizations have begun an alarming upsurge in several states.

“I think the next two to three weeks will be very telling,” Popescu said.

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