Two women are in critical condition following separate accidents that occurred just after midnight on Farrington Highway.
A third incident, a gas leak, closed Farrington Highway in Waipahu for several hours.
The first accident occurred at 12:10 a.m. Thursday near Kapolei Shopping Center when a car hit a 51-year-old woman near the Kapolei Shopping Center.
Lt. Carlene Lau, a police Traffic Division spokeswoman, said the woman was in a hospital in critical condition.
Speed and alcohol do not appear to be factors in the pedestrian accident, Lau said.
Police closed Farrington Highway until about 2 a.m. while they investigated the accident.
At 12:27 a.m., a 27-year-old woman fell out of a car driven by her boyfriend near Waianae High School.
An ambulance took the woman, a Waianae resident, to the hospital in critical condition, Lau said.
At about the same time, a gas leak closed town-bound lanes of Farrington Highway between Aniani Street and Waipahu Depot Road.
The road reopened by 6 a.m. Thursday as crews finished repairs.
On Wednesday, a 43-year-old Waipahu man died after his pickup truck rear-ended a city bus on Farrington Highway in Ko Olina.
The victim, the driver of the pickup truck, was pronounced dead at the scene at about 12:24 p.m., according to Emergency Medical Services.
Police said the bus was traveling toward Waianae on Farrington when it stopped to pick up a passenger and was struck from behind.
Police said a boy, a passenger on the bus, sustained minor injuries. He was treated at the scene, but was not transported to a hospital.
Police contraflowed the Waianae-bound lanes of Farrington Highway from 1 to 4 p.m. as Traffic Division officers investigated the crash.
This was the 52nd traffic death this year, compared with 49 at the same time last year.