Oprah Winfrey has a killer reason as to why she’s not running for president.

The famed talk show host — who sparked cries for a campaign back in January — has once again refuted rumors of a run for office, this time saying it’s because she wouldn’t make it through.

“In that political structure — all the non-truths, the bulls—t, the crap, the nastiness, the backhanded backroom stuff that goes on — I feel like I could not exist,” she told British Vogue.

“I would not be able to do it. It’s not a clean business. It would kill me.”

Talk of a possible 2020 presidential run against President Donald Trump picked up steam after Winfrey’s empowering speech at the Golden Globes.

“It’s up to the people. She would absolutely do it,” her longtime partner Stedman Graham said backstage at the event.

But in the months since, Winfrey, 64, has taken great pains to make it clear that any potential run is out of the question.

“I’ve always felt very secure and confident with myself in knowing what I could do and what I could not,” she told InStyle in March. “And so it’s not something that interests me. I don’t have the DNA for it.”

That same month, she offered up some sage advice for anyone who did decide to run.

“I will say to whoever is going to run for office, do not give your energy to the other side,” she told CNN. “Do not spend all your time talking about your opponents. Do not give your energy to that which you really don’t believe in. Do not spend an ounce of your time on that.”

Trump has been well aware of the rumblings of a Winfrey campaign, and told a rally crowd in March that he’d welcome her as an opponent because he knows “her weakness” and that running would be a “painful experience for her.”

Meanwhile, Winfrey also weighed in the #MeToo movement in her chat with British Vogue, and explained why she believes there’s actually a silver lining to the rehashing of painful stories as part of the #MeToo movement.

“People talk about ‘these are such dark times,’ but what if we shift the paradigm? Because I see it differently,” she said. “I see, ‘Isn’t this remarkable that we’re waking up?’ For years, women have endured craziness. This is what’s happening to people. They’re allowing themselves to not just become corroded, but to become hysterical. You’ve got to lean to the happiness.”