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More young people than ever will get colorectal cancer this year

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                                Colon and rectal cancers are increasing among people younger than 50. Experts have a few ideas about why.


    Colon and rectal cancers are increasing among people younger than 50. Experts have a few ideas about why.

Marisa Peters had been experiencing symptoms for years: blood on her toilet paper after going to the bathroom, changes in her stool and difficulty controlling the urge to poop. But she was in her 30s, healthy and physically active. She did not have any abdominal pain, and doctors dismissed the symptoms as hemorrhoids or normal postpartum changes after the birth of her first son. When Peters finally visited a gastroenterologist in 2021, after having her third child and experiencing worsening bleeding from her rectum along with changes in her stool consistency, an urgent colonoscopy confirmed that she had colorectal cancer.

It had been four or five years since her symptoms had first emerged. Yet “I did not expect that cancer was going to be what they found,” Peters said.

A report published by the American Cancer Society in January suggests that rates of colorectal cancer are rising rapidly among people in their 20s, 30s and 40s — even as incidence is declining in people over the age of 65.

“It’s unfortunately becoming a bigger problem every year,” said Dr. Michael Cecchini, a co-director of the colorectal program in the Center for Gastrointestinal Cancers and a medical oncologist at Yale Cancer Center. He added that early-onset colorectal cancers have been increasing by about 2% per year since the mid-1990s. This increase has moved colorectal cancer up to being the top cause of cancer deaths in men under the age of 50 and the second-leading cause of cancer deaths in women under 50 in the United States.

In fact, experts are noticing a rise in early-onset colorectal cancers around the world — a trend that they are racing to explain.

Why is colorectal cancer increasing among young people?

Colon and rectal cancers share many similarities and are typically lumped into one category, called colorectal cancer. Studies, however, show that the increase in diagnoses is mainly driven by a rise in rectal cancers and cancers found in the left, or distal, side of the colon, near the rectum. “That maybe provides an important clue for understanding what might be going on,” said Caitlin Murphy, an associate professor and cancer researcher at UTHealth Houston.

Colorectal cancers in younger people also tend to be more aggressive, and they are often found at a more advanced stage, Murphy said. But most people affected by early-onset colorectal cancer are too young to be recommended for routine cancer screenings, which have helped decrease rates in adults over 50. In 2021, the U.S. Preventive Services Task Force reduced the recommended age for starting colorectal cancer screening by just five years — from 50 to 45.

A vast majority of colorectal cancer diagnoses are still made in people 50 and older. The American Cancer Society predicted last year that roughly 153,000 new diagnoses would be made in the U.S. in 2023, of which 19,550 would be in people younger than 50. But millennials born around 1990 now have twice the risk of colon cancer compared with people born around the 1950s, while millennials’ risk for rectal cancer is about four times higher than that of older age groups, according to a study published in the Journal of the National Cancer Institute. That means diagnoses are likely to “continue going up as these higher-risk generations age,” Murphy said.

When cancer is found at a younger-than-usual age, doctors usually suspect that genetic mutations may be to blame. And some molecular studies suggest that tumors in early-onset colorectal cancers do have different mutations driving the cancer compared with tumors in older adults. Another piece of evidence that there is a genetic component: It is clear that having a first-degree relative who had colorectal cancer — or even a precancerous polyp — can increase your risk, Cecchini said. But genetic changes do not explain the full picture, he said.

Some research has linked lifestyle and dietary changes to increased rates of colorectal cancer in both young people and older adults. Recent generations have consumed more red meat, ultraprocessed foods and sugary beverages, and have been known to binge drink more frequently; between 1992 and 1998, cigarette smoking also increased before declining again, while physical activity has continuously declined for decades. All of these factors — along with the rise in obesity rates since the 1980s — are associated with cancer risk. But once again, none of them fully account for the increase in early-onset colorectal cancer.

“For a lot of these risk factors, like smoking, you have to be exposed for long periods of time before the cancer develops,” said Dr. Andrea Cercek, a co-director of the Center for Young Onset Colorectal and Gastrointestinal Cancers at Memorial Sloan Kettering Cancer Center. And many patients in their 20s and 30s do not even fit in these risk groups, she said. “Many of our patients are athletes,” she said. “Many of them were never heavy, not even in childhood.”

Experts are beginning to investigate if there are other environmental drivers of early-onset cancer. For instance, some small studies have hinted at the idea that people who develop colorectal cancer at an early age have an imbalance of “good” and “bad” bacteria in their gut. Researchers are not only looking at antibiotic use, which can alter the gut microbiome, but also nonsteroidal anti-inflammatory drugs that are used as painkillers, proton pump inhibitors that are used to counter stomach acid issues and several psychiatric medications that may be absorbed through the intestinal lining and have increased in use in recent decades, Cercek said.

Some experts believe exposure to toxic chemicals in the environment may also be to blame. “There’s patterns of environmental exposures by geography, by race, by sex, by all the things that we know colorectal cancer rates also differ by,” Murphy said.

For instance, for many years, the rates of colorectal cancer diagnoses were highest among non-Hispanic Black people, but research shows that these cancers increased more among non-Hispanic white people in the 1990s and early 2000s, Murphy said. Now, both groups have fairly similar rates of cancer. “Does this mean that white people are now being exposed to something that Black people have been exposed to for many, many years? We just don’t know yet,” Murphy said.

There are also geographic disparities in the increase in cancer, with experts seeing more cases emerge in cities and towns along the Mississippi River, in southeastern states and in Appalachia, which may be explained by occupational exposures to trace elements like arsenic, chromium and nickel, which are often used in coal production, chemical plants and other industries in those regions. So-called forever chemicals like per- and polyfluoroalkyl substances, better known as PFAS, have been linked to other cancers and could also be driving some of the increase in early-onset colorectal cancer.

“I don’t think there’s going to be one smoking gun that explains everything,” Murphy said. “It’s a whole bunch of things.”

What can you do to identify and reduce your risk?

After Peters was diagnosed and started chemotherapy, radiation and reconstructive surgery, she encouraged her younger sister and brother to get screened immediately. “Because now they had a family history of the disease,” she said.

The Colon Cancer Coalition has developed a script you can use to bring up colon and rectal cancer questions in conversations with relatives, which may help you determine whether you should be screened 10 to 15 years earlier than the current recommended age.

If you are not in contact with your immediate family or are unaware of their medical history, it is important to know the symptoms of colorectal cancer, such as unexplained abdominal pain, changes in your stool and rectal bleeding. If you have any of these symptoms, talk to a doctor and get tested to rule out cancer.

After her experience being dismissed by doctors, Peters founded an organization called Be Seen to raise awareness of symptoms and encourage people to pledge to be screened.

Colonoscopies remain the gold standard for screening because they allow medical experts to not only see where tumors are but also to remove them in the same procedure. There are now several ways patients can prepare their bowels — including liquid laxatives, pills and powders — that are not as uncomfortable as options that were available to previous generations. “I can promise you that doing a one-day cleanse to prep for a colonoscopy is far better than having poop coming out of your stomach into a bag,” Peters said. “Thankfully, it was temporary for me, but it’s not for many people.”

There is also a home test that can detect 92% of colorectal cancers through DNA in your stool, although it is less sensitive at picking up precancerous polyps and cannot be used to remove any tissue, Cercek said. A blood test that is on the horizon may further increase the number of people willing to get screened.

Even though the trend in early-onset colorectal cancers is concerning, “what I take away from it is that the time to intervene is even earlier,” Murphy said. “And certainly what is happening now is going to affect the health of generations many, many years from now.”

This article originally appeared in The New York Times.

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