COLORADO SPRINGS, Colo. » Floyd Mayweather and Manny Pacquiao have agreed to follow World Anti-Doping Agency rules for their fight in May.

That was a major sticking point that led to the end of negotiations in 2010, when the boxers first tried to put together a fight.

As part of the agreement, the U.S. Anti-Doping Agency can take blood and urine samples from both fighters at any point between now and the bout May 2 in Las Vegas. They will also be tested after the fight. Samples will be sent to labs that can test for human growth hormone, EPO and anything else on WADA’s prohibited list.

USADA CEO Travis Tygart said that by making the agreement, the fighters were sending "a strong statement of the importance of clean and safe competition."