A 2016 Nissan Armada sports utility vehicle hit a bicyclist crossing Nimitz Highway, critically injuring a woman, police said.
The accident happened at 6:40 p.m. Wednesday.
Police closed all Ewa-bound lanes of Nimitz Highway and redirected traffic to the H-1 freeway viaduct while Traffic Division officers investigated the crash scene.
The highway reopened by 10:50 p.m.
Police said paramedics initially took the 52-year-old woman to the hospital in serious condition, but her condition worsened to critical.
Police said the woman was apparently homeless.
The Armada was driven by a 37-year-old Arizona man.