NEW YORK >> The universe belongs to Marvel. “Avengers: Endgame” shattered the record for biggest opening weekend with an estimated $350 million in ticket sales domestically and $1.2 billion globally, reaching a new pinnacle in the blockbuster era that the comic-book studio has come to dominate.

The “Avengers” finale far exceeded even its own gargantuan expectations, according to studio estimates today. The movie had been forecast to open between $260 million and $300 million in U.S. and Canadian theaters, but moviegoers turned out in such droves that “Endgame” blew past the previous record of $257.7 million, set last year by “Avengers: Infinity War” when it narrowly surpassed “The Force Awakens.”

“Endgame” was just as enormous overseas. Worldwide, it obliterated the previous record of $640.5 million, also set by “Infinity War.” (“Infinity War” didn’t open in China, the world’s second largest movie market, until two weeks after its debut.) “Endgame” set a new weekend record in China, too, where it made $330.5 million.

In one fell swoop, “Endgame” has already made more than movies like “Skyfall,” ”Aquaman” and “The Dark Knight Rises” grossed in their entire runs, not accounting for inflation.

Alan Horn, Disney chairman, credited Marvel Studios and its president, Kevin Feige, for challenging “notions of what is possible at the movie theater.”

“This weekend’s monumental success is a testament to the world they’ve envisioned, the talent involved, and their collective passion, matched by the irrepressible enthusiasm of fans around the world,” Horn said in a statement.

To accommodate demand, the Walt Disney Co. released “Endgame” in more theaters — 4,662 in the U.S. and Canada — than any opening before. Advance ticketing services set new records. Early ticket buyers crashed AMC’s website. And starting Thursday, some theaters even stayed open 72 hours straight.

“We’ve got some really tired staff,” said John Fithian, president and chief executive of the National Association of Theater Owners. “I talked to an exhibitor in Kansas who said, ‘I’ve never sold out a 7 a.m. show on Saturday morning before,’ and they were doing it all across their circuit.”

Not working in the film’s favor was its lengthy running time: 161 minutes. But theaters dedicated more screens to “Endgame” than any movie before it to satiate the frenzy around Joe and Anthony Russo’s film, one which ties together the “Avengers” storyline as well as the previous 21 releases of the Marvel “cinematic universe” begun with 2008’s “Iron Man.”

For an industry dogged by uncertainty over the growing role of streaming, the weekend was a mammoth display of the movie theater’s lucrative potency. Fithian called it possibly “the most significant moment in the modern history of the movie business.”

“We’re looking at more than 30 million American and more than 100 million global guests that experienced ‘Endgame’ on the big screen in one weekend,” Fithian said. “The numbers are just staggering.”

Further boosting the results for “Endgame” were good reviews; it currently ranks as 96% fresh on Rotten Tomatoes, the best rating for any Marvel movie aside from “Black Panther.”

If there was any shadow to the weekend for the theatrical business, it was in just how reliant theaters have grown on one studio: Disney.

Disney now holds all but one of the top 12 box-office openings of all time. (Universal’s “Jurassic World” is the lone exception.) The studio is poised for a record-breaking year, with releases including “Aladdin,” ”Toy Story 2,” ”The Lion King,” ”Star Wars: The Rise of Skywalker” and “Frozen 2” on the horizon.

Following its acquisition of 20th Century Fox, Disney is expected to account for at least 40% of domestic box-office revenue in 2019, a new record of market share. The company’s “Captain Marvel” — positioned as a kind of Marvel lead-in to “Endgame” — also rose to No. 2 on the weekend, eight weeks after it opened.

But theater owners regularly speak of a “halo effect” around a movie like “Endgame.” Such sensations draw in new moviegoers and expose millions to a barrage of movie trailers.

An enormous hit was much needed for a box office that, coming into the weekend, was lagging 16% of the pace of last year’s ticket sales, according to Comscore. “Endgame” moved the needle a little, but the boost was less since “Infinity War” opened on the same weekend in 2018.

No other new wide release dared to open against “Endgame.” The guessing game will now shift to just how much higher “Endgame” can go. Given its start, it’s likely to rival the top three worldwide grossers: “The Force Awakens” ($2.068 billion in 2015), “Titanic ($2.187 billion in 1997) and “Avatar” ($2.788 in 2009).